Methods Study populations We used data on individuals aged 16 years and of self-reported European ancestry from 25 studies from the CARTA consortium: the 1958 Birth Cohort (1958BC), the Avon Longitudinal Study of Parents and Children (ALSPAC, including both mothers and children), the British Regional Heart Study (BRHS), the British Women's Heart and Health Study (BWHHS), the Caerphilly Prospective Study (CaPS), the Christchurch Health and Development Study (CHDS), Cohorte Lausannoise (CoLaus), the English Longitudinal Study of Ageing (ELSA), the National FINRISK Study (FINRISK), Generation Scotland: the Scottish Family Health Study (GS:SFHS), Genomics of Overweight Young Adults (GOYA) females, the Helsinki Birth Cohort Study (HBCS), Health2006, Health2008, the second wave of the Nord-Trndelag health study (HUNT 2), Inter99, the Northern Finland Birth Cohorts (NFBC1966 and NFBC1986), the National Health and Nutrition Examination Survey (NHANES), the MRC National Survey of Health and Development (NSHD), the Netherlands Twin Registry (NTR), Patch 2, the Rotterdam Study, the Saguenay Youth Study-Parents (SYS-P) and the Whitehall II study

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