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The following criteria should be considered when making a clinical diagnosis of oral leukoplakia: white patch/plaque that cannot be rubbed off homogeneous leukoplakia usually has well-demarcated borders non-homogeneous leukoplakia often presents red or nodular components and more diffuse borders no evidence of related chronic traumatic irritation is not reversible on elimination of apparent traumatic causes does not disappear on retracting the tissue exclusion of other white or white/red lesions Carrard and van der Waal recently proposed a list of parameters, some of which are reported in the table that may be relevant when establishing a clinical diagnosis of oral leukoplakia (Table 4)