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Therefore, the gut microbiota has the possibility to affect smoking though the pathways of microbiota-gut-brain-smoking and on the contrary gut microbial homeostasis could be a potential target for addressing tobacco use via improving brain functions [29]

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Diagnostic criteria of the nicotine withdrawal syndrome are irritability, decreased frustration tolerance, anger, aggression, attention deficit, restlessness, dysphoric mood [33]

When nicotine is absent or cigarette consumption decreases, the brain sends signals of deficiency, causing cravings