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Regulators need to take action to initiate further research into the constituent components of e-liquids and their combinations so that adequate measures can be put in place to reduce the risks as much as possible. References Abstract no: OA4384 Flavor-solvent reaction products in electronic cigarette liquids activate respiratory irritant receptors and elicit cytotoxic metabolic responses in airway epithelial cell, by Sven-Eric Jordt et al