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20 Nicotine operates by activating nicotinic acetylcholine receptors, which stimulate several signaling pathways that exacerbate tumorigenic effects, such as MEK/ERK and Sox2 via Yap1-E2F1 axis in non-small cell lung cancers

Reynolds rolled out two new cigarette brands, Camel Crisp and Newport EXP, marketing them as non-menthol even though they still have synthetic cooling agents

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