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While the Red Cross does not encourage the use of controlled substances, cannabis, cigarettes, or alcohol use does not necessarily disqualify a person from giving blood

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Endotoxemia as a Mechanism of Tobacco-Induced Damage One central mechanism underlying tobacco-related harm is endotoxemia, characterized by elevated lipopolysaccharide (LPS) levels resulting from the presence of Gram-negative bacteria in the bloodstream

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Melbourne: Cancer Council Victoria, 2018 [Accessed 6 September 2019]