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Closed system devices are any vape that does not need to be refilled with e-liquid

Nicotine is neurotoxic, affecting the central and autonomic nervous system and neuromuscular junctions by agonistically binding to the nicotinic acetyl cholinergic receptors (nAChRs) 13,28

It should be noted that the comparison of toxicity should not be made between conventional cigarettes and these devices, but rather between the use of these devices and the absence of consumption of any type of tobacco

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