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The origins of Nicotiana tabacum , or Cultivated Tobacco, are obscure

The emerging characterization of separate dopamine- and GABA (-aminobutyric acid)-dependent neural systems within the ventral tegmental area (VTA), which can mediate the acute aversive and rewarding psychological effects of nicotine, is providing new insights into how functional interactions between these systems might determine vulnerability to nicotine use

This raises the key question of whether mouse systems truly reflect the complexities of the human gut microbiotas response to tobacco smoke exposure

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The extensive use of flavors that blend strong fruit, sweet, and cooling characteristics found in both blended flavors that may have names describing these characteristics and concept flavors that do not is an important finding given that national surveys that measure use of e-cigarette flavors are often limited to single categories such as fruit, sweet, and menthol