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Weiss, Gary (2012)

Western blot analysis showed that mice treated with e-cigarette (2.4% nicotine) had increased poly (ADP ribose) polymerase (PARP1) activity associated with reduced levels of Sirtuin 1 (SIRT1)

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Due to these vascular effects, blood vessel walls thicken and blood platelet stickiness is increased, which raises the risk of clot formation and the subsequent development of heart attacks and strokes.Numerous chemicals found in cigarettes have the potential to cause harmful DNA alterations that lead to the development of cancer