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In the brain, nicotine works mostly to release other neurotransmitterslike dopamine (pleasure), norepinephrine (arousal and appetite suppression), glutamate (learning and memory), endogenous opiates, and serotonin (mood modulation)

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Neurotoxicology and teratology 30, 385389 (2008)

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The most hurtful method of smoking is the Cuban paper cigarette, where the deleterious fumes of burning paper are added to those of the exceedingly strong tobacco enveloped