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Yes, it can, especially if you have a sensitive digestive system or drink several cups of coffee each day

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doi: 10.3389/fphar.2021.726586 20 BartalesiBCavarraEFineschiSLucattelliMLunghiBMartoranaPAet al

Regarding the second topic, nicotine use in the form of tobacco smoking in first-episode psychosis: the self-medication hypothesis, the results of the current systematic review were, in the overall analysis, against the proposed hypothesis and the knowledge gained from previous studies