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Pharmacotherapy includes nicotine replacement therapy (usually a combination of nicotine patches and one or more short-acting forms such as gum, lozenges, spray or vaporiser), varenicline or bupropion (depending on country)

Traditionally, Mazatec shamans used fresh leaves in rituals for spiritual insight, healing, and divinationreferring to the plant as La Mara. These rituals are deeply ceremonial, involving quiet invocation and intention-setting

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