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ILC3s can be further subdivided according to their expression of natural cytotoxicity receptors (NCRs): NCR + ILC3s secrete IL-22 to maintain epithelial barrier integrity, whereas NCR ILC3s mainly produce IL-17A and IL-17F, which are known to induce pathogenic inflammation 15

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Specifically, the researchers found that vaping with nicotine impairs ciliary beat frequency, dehydrates airway fluid and creates more viscous phlegm

Smoke extract stimulates lung epithelial cells to release neutrophil and monocyte chemotactic activity

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