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Many studies have also shown that human and mouse cells also have ample supplies of cytochrome p450, which further converts NNN and NNK into compounds such as formaldehyde and methyldiazohydroxide that can react with DNA to form damaging adducts such as gamma-hydroxy-propanodeoxyguanosine and O6-methyl-deoxyguanosine, the researchers say

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The quantification of this western blot shows an increase in 75% of the 89 kDa fragment with no and significant changes in the full-length protein, 116 kDa (Figure 3B)