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Two, rs11539157 and rs3001723 were previously associated with schizophrenia [36], suggesting shared biological pathways between schizophrenia and smoking behaviours (Table 2)

[2] In diseased conditions due to long-term smoking, the inactivation of JNK reduces the levels of reactive nitrogen species and pro-inflammatory cytokines with more M2-like phenotype

Fact Sheet on smoking: Illness and death

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A dirty mouthpiece can harbor bacteria and make every hit feel rough