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Procedure PAR was used in this study

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To test this hypothesis for MLE-12 cells, they were treated with 0% or 8% CSE for 8 generations, then transfected with SIRT1 siRNA

[See Warnings and Precautions (5.1)] A composite safety endpoint intended to capture clinically significant neuropsychiatric (NPS) adverse events included the following NPS adverse events: anxiety, depression, feeling abnormal, hostility, agitation, aggression, delusions, hallucinations, homicidal ideation, mania, panic, paranoia, psychosis, irritability, suicidal ideation, suicidal behavior or completed suicide