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The following is a brief overview of the pathological changes, and cellular and molecular mechanisms underlying smoking-induced COPD

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Effect of Toxic Gases on Intestinal Microbiota The main toxic gases of tobacco smoke, including carbon dioxide, carbon monoxide (CO), hydrogen sulfide (H 2 S), ammonia, hydrogen, and nitrogen oxides (NO x ), are inhaled into lung and entered into blood through alveolar exchange, which affects the O 2 transport, decreases the pH of blood, and induces systemic inflammation and diseases (Sloan et al., 2010