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This prototypical pro-inflammatory cytokine is a well-established marker of CI 32,33 and not only triggers the acute phase protein response, which includes the release of fibrinogen and CRP from hepatocytes, but also stimulates antibody production and the differentiation of TH 17 and CD8 + T cells and reduces the differentiation of Tregs 34

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Data analysis Item reduction and internal construct validity: Assessed through the application of the RMT analyses 71 aiming at comparing observed data against the stringent criteria of the Rasch model (see Supplementary Table S3 for more details on the definition and acceptability criteria for RMT analysis)

The high-standard paperboard in variable thicknesses is typically used in making dual or multi-compartment box styles

It consists of an atomizer surrounded by a liquid-soaked poly-foam which acts as an e-liquid holder