It is still possible either: (1) that the supposed effect is really the cause, or in this case that incipient cancer, or a pre-cancerous condition with chronic inflammation, is a factor in inducing the smoking of cigarettes, or (2) that cigarette smoking and lung cancer, though not mutually causative, are both influenced by a common cause, in this case the individual genotype
Gay CM, Stewart CA, Park EM, Diao L, Groves SM, Heeke S, et al
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The downregulation of let - 7a and miR - 29b and the upregulation of miR - 21 induced by benzo[a]pyrene in human mammary cells were associated with the altered expression of inflammation mediators