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Many users filled out a questionnaire about the side effects that they experience when smoking an e-cig and the most commonly repeated side effect was that they felt an automatic sense of dryness and irritation in their throat

Systems toxicology analyses detected biological effects of nicotine exposure, which included up-regulation of the xenobiotic-metabolizing enzymes CYPA and FMOin the lung and metabolic effects, likely interlinked with a generalized stress response to nicotine present in the exposure aerosols []

Gotts, Jeffrey Earl (2017)

For some groups, these were their first appearances on television