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Exploratory analysis of the role of nicotine metabolism on quit outcome will be performed: (1) initial analysis will compare the proportions of patients with rapid or slow NMR who achieve the primary outcome within each treatment group using a chi-square

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Definition Chronic Obstructive Pulmonary Disease (COPD) is a common, preventable, and treatable chronic respiratory disease characterized by persistent airflow limitation that is usually progressive and associated with an enhanced chronic inflammatory response in the airways and lungs to noxious particles or gases

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