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That doesnt mean its harmless: Alcohol disrupts communication between neurons in your brain and has been shown on fMRI to alter hemodynamics (blood flow patterns across the brain, aka, neurovascular coupling)

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(eTables 6 and 7 in the Supplement)

So, the minimalist pinch method requires the user to recalculate every once in a while

It is has been reported that nicotine may be potentially harmful during pregnancy, but probably less harmful than continued smoking [2729]