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In a country like Japan, use of heat not burn products is relatively high, says Stephens

Instead of growing a product that can harm people, they are now growing mums

Oral nicotine pouches from brands like Zyn, Rouge, On!, and Velo have exploded in popularity nationwide, with the total monthly nicotine pouch sales increasing by 207% between January 2023 and April 2025, from $145.5 million to $446.8 million

This might be of clinical importance, mainly for drugs with a narrow therapeutic index, as small differences in blood concentration may lead to treatment failure or ADRs (Malm-Erjeflt et al., 2015

Each one seemed to be its own last time, wrote Nilsen, who insists that the term serial killer is inaccurate because it suggests the intention to repeat