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Journal of clinical oncology : official journal of the American Society of Clinical Oncology , 38 (9), 866876

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Traditional smoking is closely associated with a range of health issues, including respiratory diseases, cardiovascular problems, and various forms of cancer

They found that, although the research is sparse, what has been published indicates "consistent evidence for the presence of at least four substance abuse disorder criteria in heavy N2O [nitrous oxide] users." The authors concluded that nitrous oxide "could well be addictive." They advised that it should be handled as a "potentially addictive substance" until more assessments are conducted

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