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Often, nicotine is precisely the point, along with flavor

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An imbalance between histone acetylation and deacetylation, favouring acetylation, has also been observed in COPD lungs and has been associated with increased inflammatory gene expression (167, 179)

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The other component is the pod which contains concentrated liquid made up of nicotine, glycerol and propylene glycol, benzoic acid, and flavor additives