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Moreover, smokers have increased expression of CYP1A1, which can increase the metabolism ARTs that undergo metabolism through this pathway, such as dolutegravir resulting in a higher drug clearance value (Zhu et al., 2018)

Public health and anti-tobacco groups criticized the plan as not going far enough to stem an emerging public health threat

Indeed, in parts of Europe, it seemed like half the population smoked

It just depends on each individual. The profusion of flavors further complicates the public health picture

Strumylaite L, Kregzdyte R, Vaitkaitiene E (2005) Pasyvus rukymas ir vaiku kvepavimo sutrikimai [Passive smoking and respiratory health of children]