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Second, this study was conducted in April 2021, following widespread brick-and-mortar closures due to the global pandemic, which may have limited in-person tobacco and nicotine purchases and increased e-commerce 13,14

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The break-even analysis indicates that a decrease in the rates of vaping initiation in the range of 2.58% to 4.11% relative to the baseline initiation rate would be sufficient to produce public health benefits equivalent to or greater than the estimated monetized costs