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Regular RAIN practice also creates neuroplastic changes over time reducing the strength of conditioned craving responses as the association between the trigger and the automatic smoking response is repeatedly interrupted without reinforcement

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Colombi M, Dordoni C, Venturini M, Zanca A, Calzavara-Pinton P, Ritelli M

Because they are used orally and involve swallowing tobacco juice, there is increased concern about the possibility of oral, esophageal and stomach cancers arising among long-term users