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95 Several pyrazine derivatives have also been found to potentiate 5-HT binding to receptors in the central nervous system, which results in enhanced dopamine release independently of nicotine

Smoking has been associated with various cancers, chronic lung disease, heart disease, and stroke

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Answers to the validated questionnaire about loss of autonomy over nicotine use suggested similar levels of nicotine dependence between Juul users and those using other e-cigarettes, she noted, although the sensitivity of the questionnaire may have been limited by the relatively small number of participants