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These cracks come in various formssuperficial craze lines in the enamel, fractured cusps on chewing surfaces, vertical cracks stretching toward the root, or complete splits from surface to root

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Citation57 CS leads to the production of reactive oxygen species (ROS) which initiate ROS-sensitive signal transduction pathways, such as MAPKs, and various transcription factors, including NF-kB Citation15 resulting in an aberrant cytokine profile