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Abbreviations CSE: Cigarette smoke extract Drp1: Dynamin-related protein 1 Fis1: Mitochondrial fission 1 protein Mfn1 and Mfn2: Mitofussion1 and 2 Mn-SOD: Manganese Superoxide Dismutase Opa1: Optic atrophy type 1 OXPHOS: Oxidative phosphorylation PBEC: Primary Bronchial Epithelial Cells PINK1: PTEN-induced putative kinase 1 PPARGC1: Proliferator-activated receptor gamma co-activator 1-alfa ROS: Reactive Oxygen Species Tfam: Mitochondrial transcription factor A