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Unlike Winston, who holds his cheap cigarettes clumsily constantly afraid of them falling to pieces, OBrien handles them with a remarkable grace: It came out even in the gesture with which he thrust a hand into his pocket, or manipulated a cigarette

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5.2 Influence of altered mitochondrial dynamics on inflammation Altered mitochondrial dynamics, which include the processes of mitochondrial fission, fusion, biogenesis, and mitophagy, play a critical role in regulating cellular homeostasis and can significantly influence inflammatory responses (Mills and ONeill, 2016)