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According to an aspect of the present invention, there is provided a smoking article comprising a rod of smokeable material, and an elongate filter coupled adjacent to the rod of smokeable material, wherein the diameter of the whole, or a portion of the filter adjacent to the rod of smokeable material is greater than the diameter of the rod of smokeable material

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You're more likely to get it if your immune system isn't working well, perhaps because of cancer or HIV/AIDS

But, as mentioned, the type of leaf used will affect nicotine content the most