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Of the Phase III pharmacotherapies, lorcaserin, taranabant, topiramate, and bupropion with naltrexone all demonstrated significant weight loss compared to placebo at 12 months

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We therefore performed a sensitivity analysis reducing F AA , F TA and the calculated RR of drinking ten units of alcohol, or smoking ten cigarettes per week, by a factor of 50% for cancers in which both alcohol and tobacco contribute (Additional file 1: Table S6)

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