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Roggen and his colleagues questioned whether cannabinoid concentration was the most important factor in determining the drugs intoxicating effectand what other things contribute to an enjoyable experience

Lynch, by his own account, smoked his first cigarette at the age of eight (which is four years older, incidentally, than Sailor Ripley in Wild at Heart)

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As ably as he crafted his films, Lynch back in 1992 summed up the tension that would turn out to mark his entire oeuvre