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It inhibits the growth of human A375 melanoma, A431 epidermoid carcinoma, A549 lung, MES-SA uterine sarcoma, and MCF-7 breast cancer cells ( IC 50 =3 nM for all).2 ()-Cryptopleurine inhibits hypoxia-induced gene expression in a hypoxia response element (HRE) reporter assay ( IC 50 =8.7 nM).3 ()-Cryptopleurine (500 g/mL) prevents lesion formation in tobacco (N