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Free nicotine: the bioavailable form responsible for the buzz Bound nicotine: less absorbable, contributes to slower release Moisture & texture: determine how evenly nicotine spreads and absorbs under the lip Why Synthetic Can Feel Smoother Synthetic nicotine doesnt inherently hit harder or softer, its chemically identical to tobacco-derived nicotine

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Bupropions dopaminergic activity also drives its smoking cessation mechanism

These range from non-serious issues to serious adverse events (SAEs) including hospitalization, disability, or death

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