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One study has estimated that the average smoker consumes 36 g of 4-aminobiphenyl, 1,309 g of o-toluidine and 98.2 g of -naphthylamine each year

Cigarette smoking and lung cancerrelative risk estimates for the major histological types from a pooled analysis of casecontrol studies

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The shift in LC trends by histological type that occurred over the last several decades had been hypothesized to be due to changes in cigarette composition and design 31,32