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Gottlieb said the FDA does not want to make nicotine products harder to get

Zeng et al., 2021)

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They possess three domains: a RING1 domain that binds to Ub-loaded E2, a RING2 domain that catalyzes a transthioesterification reaction with a cysteine residue and receives ubiquitin from RING1, and an in-between-RING (IBR) domain 15