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So Selye began to suggest that subjecting an animal to prolonged stress led to tissue changes and physiological changes with the release of certain hormones, that would then cause disease and ultimately the death of the animal." And so the idea of stress and it's potential costs to the body was born

When participants were followed up 10 years later, researchers found that long-term exposure to all of the pollutants was linked to an increased percentage of emphysema seen on a CT scan

1998 Carcinogenesis 19 : 117124 Culp S, Roberts D, Talaska G, Lang N, Fu P, Lay Jr J, Teitel C, Snawder J, Von Tungeln L, Kadlubar F

Age estimated to be around mid 20's