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Electronic cigarettes have not been well studied and are not recommended

Filler, the lowest grade, makes up the innermost layers

JUUL, which comes in flavors such as fruit medley, mango, cool cucumber and creme brulee, captured more than half of the e-cigarette market share in just two years on the market

An alternative hypothesis is depicted on the right, in which inhalation of chemicals common in e-cigarette aerosols (propylene glycol, glycerin, nicotine, or THC) alters the inflammatory state of the lungs, including changing alveolar macrophages to a proinflammatory phenotype with the release of inflammatory cytokines (indicated by yellow circles), such that a second hit causes a pathologic inflammatory response