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When Tarrans team administered nicotine to immune cells cultured in the laboratory at concentrations like those seen in vapers sputum and lung fluid they observed that the cells overproduced the proteases

Although, assuming 15 puffs per e-cigarette unit, carbonyls produced by PG or glycerol heating would be below the maximum levels found in a conventional cigarette combustion (Table 2) [51, 62]

Cartwright, Carry on Smoking: Public Relations and Advertising Strategies of American and British Tobacco Companies since 1950, Business History , 47(3), 2005, 421433