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These biomarkers were benchmarked against three epigenetic scores for smoking: EpiSmokEr score 7,63,64 , and two scores derived from previous GS analyses on smaller subsets of the dataset - one based on BayesR weights 59 , the other via lasso penalised regression by McCartney et al

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In the confusion matrices, the x-axis denotes the ground truth classes (the actual annotated categories in the dataset), while the y-axis represents the predicted classes (the models classification outputs)

The most commonly used nicotine products include nicotine patches, gum, sprays, inhalers, and lozenges