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Declare estimated sales volume Forecasted volumes must be submitted for each product type and size

3 Williamson LM, Hull D, Mehta R, Reeves WG, Robinson BH, Toghill PJ

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Ibuprofen produced an elevation of plasma lithium levels and areduction in renal lithium clearance in a study of eleven normal volunteers.The mean minimum lithium concentration increased 15%and the renal clearance of lithium was decreased by 19% during thisperiod of concomitant drug administration.This effect has been attributed to inhibition of renal prostaglandinsynthesis by ibuprofen