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Abreu-Villaa Y, Seidler FJ, Tate CA, Slotkin TA (2003) Nicotine is a neurotoxin in the adolescent brain: critical periods, patterns of exposure, regional selectivity, and dose thresholds for macromolecular alterations

Centers that treat 50 or more mesothelioma patients annually have the most experience with this rare cancer

Tobacco smoke has been reported to cause not only a decrease in sperm motility (although controversial), sperm concentration, and an increase in abnormal sperm morphology, but also abnormal protein expression, and both genetic and epigenetic aberrations in spermatozoa (Pereira et al

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The latter is responsible for the reduction in the plasma concentration of metronidazole in smokers as a result of the transcriptional mechanism of the CYP1A2 isoform