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In such a case, youth who start smoking following e-cigarettes may have a risk of tobacco-related illness similar to that of youth who start smoking without a history of e-cigarettes

If notable asymmetry is detected, it suggests potential bias that may influence the NMA results, warranting caution in interpreting the findings

Systemic IL-33 produced by keratinocytes synergizes with intestinal IL-25 to drive the expansion and activation of intestinal Type 2 innate lymphoid cells (ILC2s) that produces IL-4 and IL-13, which increases the number of mucosal MCs in the intestine (Olbrich et al., 2020)

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