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It comes from a 2010 meta-analysis of Social Relationships and Mortality Risk (see Figure), which benchmarked the size of the effect that lacking social connection has on risk for premature mortality against the effect of other known risk factors, including smoking

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We found that, even after factoring in the heterogeneity between studies and other sources of uncertainty, smoking has a strong-to-very-strong association with a range of health outcomes and confirmed that smoking is irrefutably highly harmful to human health

Despite the fact that I was having a really hard time by the end of the week, I didnt go out, and I didnt communicate with anybody, I considered the first cigarette-free week can to be a success

Step 1: systematic review approach to literature search and data extraction Informed by the systematic review approach we took for the GBD 2019 (ref