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The research, commissioned by the Department for Health and Social Care (DHSC), also highlights the positive impacts of quitting smoking

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Or Mama Told Me (Not to Come) being as big without the humor that Cory Wells injected into it

Strong recommendations are typically based on high-certainty evidence (i.e., high confidence in the estimate of the effect of an intervention) and may recommend in favour of an intervention (when there is high confidence of net benefit) or against an intervention (when there is high confidence of net harm)

Using senna long term may also alter electrolyte balance, which can lead to muscle weakness, disordered heart function and liver damage.