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In A Counterblaste to Tobacco (1604), James VI of Scotland and I of England described smoking as "A custome lothsome to the eye, hatefull to the Nose, harmefull to the braine, dangerous to the Lungs, and in the blacke stinking fume thereof, neerest resembling the horrible Stigian smoke of the pit that is bottomelesse", and urged his subjects not to use tobacco

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Considering Californias smoking rate historically underperforms the national average we should expect the states smoking rate to be even lower

The role of benign joint hypermobility in the pain experience in juvenile fibromyalgia: an observational study

28 , 511515, doi:10.1038/nbt.1621 (2010)