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Biliary stricture developed in six, six, and seven patients at the third, fifth and 10th year in the smoking patients after the onset of CP, the cumulative rates of which were 10.9% (95% CI: 6.515.3%), 10.9% (95% CI: 6.515.3%), and 12.7% (95% CI: 6.918.5%), and in four, eight, and 11 patients in the drinking patients, the cumulative rates of which were 5.0% (95% CI: 2.67.4%), 10.0% (95% CI: 6.713.3%), and 13.8% (95% CI: 9.617.9%), while in 108, 124, and 149 patients in the controls, the cumulative rates were 9.1% (95% CI: 8.210.0%), 10.4% (95% CI: 9.411.4%), and 12.5% (95% CI: 11.313.7%), respectively
